نتایج : phage display (1 مورد) مرتب سازی:

  • molecular considerations for development of phage antibody libraries

    Keyword(s): adalimumab- / antibody- / at 008- / belimumab- / bi 204- / briakinumab- / cixutumumab- / fresolimumab- / gantenerumab- / immunoglobulin f(ab) fragment- / lexatumumab- / mapatumumab- / monoclonal antibody- / mor 101- / mor 102- / mor 103- / mor 208- / necitumumab- / ramucirumab- / raxibacumab- / single chain fragment variable antibody- / tralokinumab- / unclassified drug- / virus vector- / alzheimer disease- / anthrax-سیاه زخم / antibody library- / asthma- / atherosclerosis- / autoimmune disease- / biopanning- / brain cancer- / breast cancer- / burn-سوختگی / chronic lymphatic leukemia- / colon cancer- / colorectal cancer- / crohn disease- / enzyme linked immunosorbent assay- / escherichia coli- / fibrosing alveolitis- / gene amplification- / gene library- / genetic recombination- / genetic transfection- / host cell- / human- / immunoglobulin heavy chain gene- / immunoglobulin light chain gene- / kidney carcinoma- / lung cancer- / lung non small cell cancer- / melanoma- / metastasis- / molecular cloning- / multiple myeloma- / neoplasm- / nonhodgkin lymphoma- / nonhuman- / phage display- / phagemid- / priority journal- / prostate adenocarcinoma- / psoriasis- / reverse transcription polymerase chain reaction- / review- / rheumatoid arthritis- / systemic lupus erythematosus- / virion- / animals- / antibodies,monoclonal- / antibodies,viral- / bacteriophages- / humans- / peptide library- / recombinant proteins- / technology,pharmaceutical- / viral vaccines- / virology-
    Author(s): tohidkia,m.r / barar,j / asadi,f / omidi,y

    nowadays,phage display libraries are used as robust tools for discovery and evolution of peptide/protein based drugs as well as targeting molecules,in particular monoclonal antibodies (mabs) and its fragments (i.e.,scfvs,fabs,or bivalent f(ab′)2).phage display technology,as a molecular diversity approach,enables selection of antibody fragments (e.g.,scfv/fab) with high affinity,specificity and effector functions against various targets.however,such selection process itself is largely dependent upon various molecular factors such as methods for construction of phage library,phage/phagemid vectors,helper phage,host cells and biopanning processes.the current review article provides important molecular considerations for successful development of phage antibody libraries that may be used as a platform for translation of antibody fragments into viable diagnostic/therapeutic reagents.© 2012 informa uk,ltd.