Investigate the role of glutathione S Transferase (GST) polymorphism in development of hypertension in UAE population

Background: GST is a family of enzymes that are important in protection of the body against oxidative stress.Objectives: Investigate the association between GSTT1 and GSTM1 polymorr' ism and hypertension.Materials and Methods: GSTT1 and GSTM1 genotypes were detected by CR.The fragments were then analyzed by agarose gel electrophoresis.Results: There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4,P > 0.05 and OR = 1.6,P> 0.05) Conclusions: GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.

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