Case report of a patient undergoing peritoneal dialysis with encapsulating peritoneal sclerosis superimposed with calciphylaxis

Introduction: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD).Tamoxifen has been generally well-tolerated,even without randomized controlled trials.Case Presentation: Herein,we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously.We also provide a comprehensive discussion about the association between EPS and calciphylaxis.Moreover,although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production,it may worsen the calciphylaxis due to a hypercoagulable state.Conclusions: We suggest avoiding the use of tamoxifen for EPS in patients with superimposed calciphylaxis.© 2016,Iranian Red Crescent Medical Journal.

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