Antimicrobial susceptibility patterns of Ureaplasma urealyticum and Mycoplasma hominis isolated from pregnant women

Background: Mycoplasma hominis and Ureaplasma urealyticum bring with them an increased risk of pregnancy complications,such as premature membrane rupture,vaginitis and preterm birth.Objectives: The present investigation was carried out to study the prevalence of M.hominis and U.urealyticum in pregnant women and to study their resistance against commonly used antibiotics.Materials and Methods: Three hundred and fifty high vaginal swabs were taken from pregnant women.Commercial Mycoplasma IST-2 kit was used for bacterial isolation.The results of the kits were confirmed using the PCR.The pattern of antibiotic resistance was determined using the disk diffusion method.Results: Of 350 samples collected,32 samples (9.14%) were positive for U.urealyticum and 10 samples (2.85%) were positive for M.hominis (P = 0.025).Both U.urealyticum and M.hominis were simultaneously detected in 1.14% of samples.In addition,40-45-year-old pregnant women had the highest levels of U.urealyticum (27.5%),M.hominis (12.5%),and both bacteria (7.5%).U.urealyticum and M.hominis isolates harbored the highest levels of resistance against ciprofloxacin,ofloxacin,erythromycin,and tetracycline.Both isolates were susceptible to pefloxacin,clarithromycin,josamycin,and pristinamycin.Conclusions: According to the direct correlation between the increase in the prevalence rate of genital mycoplasmas and increased age of pregnancy,initially,it is better to prevent pregnancy at older ages,and then,should a pregnancy occur,the highest levels of health cares should be provided to older pregnant women.© 2015,Iranian Red Crescent Medical Journal.

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